Clomiphene citrate therapy and unexplained subfertility

Oestrogen receptor (ER) and progesterone receptor (PR) binding site levels were determined using an assay system based upon that of King et al. Endometrial samples were obtained from 49 subfertility patients on clomiphene citrate (Clomid) therapy admitted to hospital for dye laparoscopy. An assay system based on that of Kato and Seto using synthetic androgen R1881 was used to measure androgen receptor (AR) binding sites in endometrial tissue obtained in the above patients. It is concluded that a cyclic variation was observed in ER and PR binding sites in women on Clomid therapy. No cyclic variation was observed in AR binding sites of women on Clomid therapy.