Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Background subtraction in technetium-99m-MAG3 renography

A Taylor1, K Thakore, R Folks

  • 1Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|January 1, 1997
PubMed
Summary

Background correction methods significantly impact the accuracy of renal function estimates using 99mTc-mercaptoacetyltriglycine (MAG3). Automated regions of interest (ROIs) offer better reproducibility for 99mTc-MAG3 studies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of topical flurbiprofen on trabeculectomy.

Journal of glaucoma·2009
Same author

Smooth estimation of the reliability function.

Lifetime data analysis·2002
Same author

Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings.

The American journal of psychiatry·2001
Same author

Risk factors for premature ovarian failure in females with galactosemia.

The Journal of pediatrics·2000
Same author

Platelet reactivity in depressed patients treated with paroxetine: preliminary findings.

Archives of general psychiatry·2000
Same author

Multicenter trial validation of a camera-based method to measure Tc-99m mercaptoacetyltriglycine, or Tc-99m MAG3, clearance.

Radiology·1997

Area of Science:

  • Nuclear medicine
  • Radiopharmacology
  • Renal imaging

Background:

  • Accurate estimation of split renal function and camera-based clearances is crucial in nuclear medicine.
  • Correction methods can introduce errors in these estimations, particularly with 99mTc-mercaptoacetyltriglycine (MAG3).

Purpose of the Study:

  • To evaluate the accuracy of different background correction methods for 99mTc-MAG3 renal imaging.
  • To determine the optimal background option and time interval for minimizing error in split renal function assessment.

Main Methods:

  • Fifteen single-kidney patients received 99mTc-MAG3 injections.
  • Counts were analyzed using manual (inferior, lateral), automated (elliptical, perirenal), and no background correction ROIs.
  • Error was quantified by estimating relative and absolute kidney function in a phantom kidney model across various time intervals.

Related Experiment Videos

Main Results:

  • No background correction and inferior ROI correction resulted in significantly greater errors (p < 0.05) for all time intervals.
  • Lateral, elliptical, and perirenal ROIs showed no significant difference in error compared to zero.
  • Automated ROIs demonstrated potential for improved reproducibility in sequential studies.

Conclusions:

  • No background correction leads to the highest error in 99mTc-MAG3 studies.
  • Inferior ROI correction consistently underestimates background and should be avoided.
  • Automated ROIs are recommended for 99mTc-MAG3 due to their reproducibility, with no significant difference in error compared to lateral ROIs.