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Fluorine-18-FPCT: a PET radiotracer for imaging dopamine transporters
M M Goodman1, R Keil, T M Shoup
1Emory Center for Positron Emission Tomography, Atlanta, Georgia, USA.
Summary
A new fluorine-18 labeled compound, FPCT, shows promise as a dopamine transporter imaging agent. Studies indicate high uptake in the brain
Area of Science:
- Radiochemistry
- Neuroscience
- Molecular Imaging
Background:
- Dopamine transporters (DAT) are crucial in neurotransmission.
- Developing novel imaging agents for DAT is essential for understanding neurological disorders.
Purpose of the Study:
- To synthesize and evaluate a new fluorine-18 labeled tracer, FPCT, for dopamine transporter imaging.
Main Methods:
- Synthesis of [18F]FPCT via alkylation using [18F]fluoro-3-iodopropane.
- Tissue distribution studies in rats.
- Positron Emission Tomography (PET) imaging in rhesus monkeys.
- Analysis of plasma metabolites using HPLC.
Main Results:
- [18F]FPCT demonstrated high striatal uptake and good striatal-to-cerebellum ratios in rats.
- PET imaging in monkeys showed high putamen uptake and retention with favorable putamen-to-cerebellum ratios.
- Metabolic analysis confirmed the stability of [18F]FPCT in plasma.
Conclusions:
- [18F]FPCT exhibits excellent properties for PET imaging of dopamine transporters.
- This tracer holds significant potential for clinical applications in diagnosing and monitoring DAT-related conditions.