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Related Experiment Videos

Weight gain induced by clozapine

M Hummer1, G Kemmler, M Kurz

  • 1Department of Biological Psychiatry, Innsbruck University Clinics, Austria.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|December 1, 1995
PubMed
Summary

Clozapine significantly increases weight gain in patients, often within 12 weeks. Initial body weight influences this side effect, which was higher compared to haloperidol treatment.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Medicine

Background:

  • Weight gain is a common concern with antipsychotic medications.
  • Understanding clozapine-induced weight gain is crucial for patient management.

Purpose of the Study:

  • To investigate the incidence and time course of clozapine-induced weight gain.
  • To compare weight gain between clozapine and standard antipsychotics (haloperidol).

Main Methods:

  • Observational study involving 81 patients treated with clozapine.
  • Comparison group received haloperidol (n=11).
  • Weight changes were monitored, and influencing factors were analyzed.

Main Results:

  • 35.7% of patients on clozapine experienced significant weight gain.

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  • Weight gain typically occurred within the first 12 weeks of clozapine treatment.
  • Higher weight increase was observed with clozapine compared to haloperidol.

    • Conclusions:

    • Clozapine is associated with significant weight gain, particularly in the initial treatment phase.
    • Initial body weight is a key factor influencing clozapine-induced weight gain.
    • Weight gain on clozapine is more pronounced than with haloperidol.