[Prognosis of lymphogranulomatosis in children with mediastinal damage]

From 1982 to 1991, a total of 132 children with lymphogranulomatosis involving the mediastinum were studied. The comparative analysis of their survival was made on the basis of clinical and laboratory findings which might affect prognosis. Factorial analysis identified 9 unfavourable factors significantly influencing the survival rates. Their predictive value was defined from the informative rate (IR) and distributed in the following decreasing order: patient incompliance, Stage IV, the mediastinal thoracic index of more than 50%, the histological types: modular sclerosis and lymphoid depletion, the patient age of over 10 years, higher haptoglobulin and ceruloplasmin levels, leukocytosis (greater than 8 x 10(9)) g/l, diseases of the lung and pleura. The findings show it expedient to consider the above unfavorable factors in defining a risk group to apply a differential approach to treating patients with lymphogranulomatosis involving the mediastinum.