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[Multimodality treatment for retinoblastoma in children]
L A Durnov1, B M Belkina, V G Poliakov
1NII of Pediatric Oncology, ONTs RAMN, Moscow.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
|January 1, 1996
Summary
This study presents a comprehensive treatment program for retinoblastoma in children, improving organ-saving therapy success rates. The program achieved significant tumor regression and high survival rates, especially in bilateral cases.
Area of Science:
- Pediatric Oncology
- Ophthalmology
- Cancer Treatment Modalities
Context:
- Retinoblastoma is a common pediatric eye cancer.
- Staging by the TNM system is crucial for treatment planning.
- Organ-saving therapy aims to preserve vision and the eye.
Purpose:
- To evaluate a comprehensive treatment program for unilateral and bilateral retinoblastoma.
- To assess the efficacy of teletherapy and polychemotherapy in organ-saving treatment.
- To determine the impact of the program on tumor regression, survival, and recurrence rates.
Summary:
- A program treating 202 children with retinoblastoma (uni- and bilateral) using teletherapy and polychemotherapy was implemented.
- Complete or partial tumor regression was achieved in 62% of cases, with 62% of patients preserving their organ of vision.
- Five-year survival rates were high (92% unilateral, 83% bilateral), with low recurrence and metastasis rates (10% conservative, 7.7% overall).
Impact:
- Expanded indications for organ-saving therapy in retinoblastoma.
- Demonstrated the effectiveness of multimodality treatment in improving outcomes.
- Provided evidence for improved longevity and vision preservation in pediatric retinoblastoma patients.