[Poor responders followed for 3 years in an IVF program]

Our study consisted of a population of 100 women who represented an insufficient response to the induction of ovulation. We researched to find out which therapeutic approach, of the subsequent attempts to IVF would give greater hope to a better response. Two groups were individualized: in the first group (62 women) we obtained at least once, 3 oocytes (288 attempts), in the second group (38 women) we always obtained less than 3 oocytes. In the first group, in order to raise the pregnancy rate it was necessary to raise the rate of E2/oocyte. There fore raising the duration of stimulation and the quantity of ampullage of hMG. The long protocol, hMG, produced the best results. In the second group, the results were always worse it was more than a problem of protocol, it was a problem of the patients. In reality, the future of therapy for lower responsive patients is probably biological with hatching today and the possibilities with oocytary maturation in vitro in the near future.