Related Experiment Videos
[Poor responders followed for 3 years in an IVF program]
B Rossin-Amar1, G M Mercier, A Pascal
1FIV Marseille-Provence, Unité de Médecine de la reproduction, Hôpital Fondation St Joseph, Marseille.
Contraception, Fertilite, Sexualite (1992)
|September 1, 1996
Summary
For women with poor response to ovulation induction, optimizing the long protocol using human menopausal gonadotropin (hMG) improved IVF outcomes. Future therapies may involve biological approaches for these patients.
Area of Science:
- Reproductive endocrinology and infertility treatments.
- In vitro fertilization (IVF) protocols and patient response.
Context:
- Investigating suboptimal responses to ovulation induction in 100 women undergoing IVF.
- Evaluating therapeutic strategies for subsequent IVF attempts in women with poor ovarian response.
Purpose:
- To determine the most effective IVF therapeutic approach for women with insufficient response to ovulation induction.
- To identify factors influencing oocyte yield and pregnancy rates in poor responders.
Summary:
- The study divided 100 women into two groups based on oocyte retrieval (≥3 vs. <3 oocytes). The group achieving ≥3 oocytes showed improved pregnancy rates by increasing estradiol (E2) per oocyte, achieved through longer stimulation and higher doses of hMG using the long protocol.
- The long protocol with hMG yielded the best results in the group with a better response. The group with consistently fewer than 3 oocytes faced patient-specific challenges, suggesting protocol adjustments alone were insufficient.
Impact:
- Optimizing the long IVF protocol with hMG can enhance pregnancy rates in women with a moderate response to ovulation induction.
- Highlights the need for personalized or biological therapies for patients with inherently low ovarian response, pointing towards future advancements like assisted hatching and in vitro oocyte maturation.