[Evolution of intra-cytoplasm sperm injection activities from 1992 to 1995. FIVNAT]

There was a large increase in the number of ICSI realised in France between 1992 and 1995, reaching 20% of all the OPU in 1995. Approximatively 95% of all the ICSI were realised for male infertility, more than 4% being performed with semen from epididymis or vas deferens. Women were slightly younger (32.7 +/- 4.6 years) than for conventional IVF, but infertility duration and stimulation regimens were the same. The pregnancy rate increased since 1992, reaching 23% in 1995, higher than in conventional IVF, and fertilization rate reached the same level (50%). The main success factors were women's age, the number of transferred embryos and the experience of the biologists attested by its length. The increased pregnancy chances associated with a high number of transferred embryos has to be considered. There could exist an increase in multiple pregnancies in the next future.