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[Neonatal diabetes mellitus associated with an autoimmune disease]
1Service de néonatologie-maternité et de réanimation pédiatrique, Brest, France.
Abstract
Background:
Insulin-dependent diabetes mellitus can be associated to an auto-immune disease. A similar association may be seen in the neonate.
Case Report:
A one-day-old boy was admitted for ketoacidosis due to diabetes mellitus. Investigation showed that he also suffered from an auto-immune enteropathy with several types of autoantibodies, particularly anti-enterocytes antibodies. Immunotherapy was ineffective. Multi-organ lesions developed subsequently, particularly a pulmonary disease responsible for the death at the age of 2 years.
Conclusion:
Physiopathology of this association remains unclear and the report of further cases should help improve our knowledge.