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[Neonatal diabetes mellitus associated with an autoimmune disease]
1Service de néonatologie-maternité et de réanimation pédiatrique, Brest, France.
Insights
Autoimmune enteropathy in a neonate presented with diabetic ketoacidosis. This rare condition involved autoantibodies and led to multi-organ failure, highlighting the need for further research into this association.
Area of Science:
- Pediatric Endocrinology
- Autoimmune Diseases
- Neonatal Medicine
Background:
- Autoimmune diseases can be linked to insulin-dependent diabetes mellitus.
- Similar associations have been observed in neonates.
Observation:
- A one-day-old infant presented with diabetic ketoacidosis.
- The infant was diagnosed with autoimmune enteropathy, exhibiting various autoantibodies, notably anti-enterocyte antibodies.
Findings:
- Immunotherapy proved ineffective in treating the infant's condition.
- The infant developed multi-organ lesions, including pulmonary disease, ultimately leading to death at two years of age.
Implications:
- The physiopathology of autoimmune diabetes and enteropathy in neonates remains unclear.
- Reporting additional cases is crucial for advancing our understanding of this complex association.
Background:
Insulin-dependent diabetes mellitus can be associated to an auto-immune disease. A similar association may be seen in the neonate.
Case Report:
A one-day-old boy was admitted for ketoacidosis due to diabetes mellitus. Investigation showed that he also suffered from an auto-immune enteropathy with several types of autoantibodies, particularly anti-enterocytes antibodies. Immunotherapy was ineffective. Multi-organ lesions developed subsequently, particularly a pulmonary disease responsible for the death at the age of 2 years.
Conclusion:
Physiopathology of this association remains unclear and the report of further cases should help improve our knowledge.