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[Endogenous digoxin-like factor in myocardial infarction]

A I Bagrov1, E A Kuznetsova, O V Fedorova

  • 1Clinic of Urgent Cardiology, NII of Emergency Care of II Dzhanelidze, Saint-Petersburg.

Klinicheskaia Meditsina
|January 1, 1996
PubMed
Summary

Endogenous digoxin-like factor (EDLF) levels increase in the first days after acute myocardial infarction (AMI). This rise in EDLF may contribute to ventricular arrhythmias and congestive heart failure following AMI.

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Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Endogenous digoxin-like factor (EDLF) is a substance found in the body.
  • Its role in acute myocardial infarction (AMI) and associated complications is not fully understood.

Purpose of the Study:

  • To investigate if EDLF concentrations increase after AMI.
  • To determine if elevated EDLF contributes to ventricular arrhythmias or congestive heart failure post-AMI.

Main Methods:

  • Retrospective study of 54 patients with first transmural AMI.
  • Plasma EDLF levels measured via DELFIA digoxin fluoroimmunoassay during days 1-14 post-AMI.
  • Comparison with 16 unstable angina patients and 8 healthy controls.

Main Results:

  • EDLF levels were significantly higher on day 1 post-AMI compared to controls and unstable angina patients.

Related Experiment Videos

  • Patients with ventricular fibrillation had higher EDLF levels than those without.
  • Patients with congestive heart failure had lower EDLF levels than those without.

    • Conclusions:

    • Plasma EDLF increases in the early period after AMI.
    • EDLF may play a role in the development of arrhythmias and congestive heart failure following AMI.