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[Clinical pharmacology of 2-chlorodeoxyadenosine (Cladribine)]
1Zakładu Farmakologii Akademii, Medycznej w Lodzi.
Przeglad Lekarski
|January 1, 1996
Abstract:
2-chlorodeoxyadenosine (2-CdA) is a simple nucleoside derived from deoxyadenosine by substituting chloride for hydrogen in 2' position of the purine ring, which renders it resistant to degradation by adenosine deaminase. Many studies have revealed high efficiency of 2-CdA in the treatment of lymphoid malignancies. Hairy cell leukemia is notably responsive to 2-CdA, with 85% of patients entering complete remissions after treatment of this drug.