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Updated: Aug 14, 2026

Single Molecule Methods for Monitoring Changes in Bilayer Elastic Properties
Published on: November 3, 2008
Mechanisms by which small molecules alter ionic permeability through lipid bilayer membranes
Abstract:
Small molecules may be particularly effective cytotoxic agents by way of altering ionic permeability in cell and organelle membranes. The mechanisms by which such molecules may acte on membrane permeability are examined here in light of the rather precise understanding of the mechanisms by which ionic permeability is induced and altered in lipid bilayer membranes. In particular, the influence of specific changes in membrane composition on the kinetics of direct and carrier mediated transport of ions are examined in detail and related to the electrical potentials originating from dipolar residues at the membrane surface.
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