[Stability of Marburg virus to lyophilization process and subsequent storage at different temperatures]

The data on Marburg virus resistance to freeze-drying in the presence of protective media and on a decrease in the freeze-dried virus biological activity at positive and negative temperatures are presented. Using the results of the experiments, kinetic parameters of virus thermoinactivation were determined for long-term storage at 20 and 37 degrees C. The rate of Marburg virus inactivation was comparable to the rates reported in the literature for para-, mixo- and toga-viruses. The conclusion is made on feasibility of prolonged storage of Marburg virus under negative temperatures.