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Related Experiment Videos

A histamine-induced decrease of action potential duration in cardiac muscle mediated by the H2 receptors

F Ledda, A Mugelli, L Mantelli

    Agents and Actions
    |July 1, 1977
    PubMed
    Summary
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    Histamine exposure shortens cardiac action potential duration in guinea pig hearts. This effect, mediated by H2 receptors, involves calcium influx and impacts potassium permeability, influencing heart repolarization.

    Area of Science:

    • Cardiovascular Physiology
    • Electrophysiology
    • Pharmacology

    Background:

    • Histamine is a biogenic amine with diverse physiological roles.
    • Its direct effects on cardiac electrophysiology, particularly action potential duration, require further elucidation.

    Purpose of the Study:

    • To investigate the impact of histamine on the cardiac action potential in guinea pig ventricular tissue.
    • To determine the receptor subtype involved and the underlying ionic mechanisms.

    Main Methods:

    • Ventricular strips from guinea pig hearts were used.
    • Electrical stimulation at a constant rate was applied.
    • Effects of varying histamine concentrations (10(-7)--10(-5) M) and burimamide were assessed.

    Main Results:

    Related Experiment Videos

    • Histamine (above 10(-6) M) consistently decreased action potential duration.
    • No significant changes were observed in other electrophysiological parameters.
    • Burimamide blocked the histamine-induced shortening of action potential duration.

    Conclusions:

    • Histamine shortens cardiac action potential duration via H2 receptor activation.
    • This effect is likely mediated by increased intracellular calcium, influencing potassium permeability.
    • The findings provide insights into histamine's role in cardiac repolarization.