Related Experiment Video
Updated: Jul 25, 2026

Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart
Published on: August 10, 2018
Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency
S Offermanns1, V Mancino, J P Revel
1Division of Biology 147-75, California Institute of Technology, Pasadena, CA 91125, USA.
Abstract:
Heterotrimeric GTP-binding proteins (G proteins) participate in cellular signaling and regulate a variety of physiological processes. Disruption of the gene encoding the G protein subunit alpha13 (Galpha13) in mice impaired the ability of endothelial cells to develop into an organized vascular system, resulting in intrauterine death. In addition, Galpha13 (-/-) embryonic fibroblasts showed greatly impaired migratory responses to thrombin. These results demonstrate that Galpha13 participates in the regulation of cell movement in response to specific ligands, as well as in developmental angiogenesis.
Related Concept Videos
Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Regulation of Angiogenesis and Blood Supply
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
Intracellular Signaling Affects Focal Adhesions
Some...

