Related Experiment Videos
Effect of inhaled indomethacin on exercise-induced bronchoconstriction in children with asthma
T Shimizu1, H Mochizuki, M Shigeta
1Department of Pediatrics, Gunma University School of Medicine, Japan.
Insights
Inhaled indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), effectively reduced exercise-induced bronchoconstriction (EIB) in children with asthma. This treatment improved lung function and oxygen saturation after exercise challenges.
Area of Science:
- Pediatric Pulmonology
- Pharmacology
- Respiratory Medicine
Background:
- Exercise-induced bronchoconstriction (EIB) is a common condition in children with asthma.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown potential in managing inflammatory airway conditions.
Purpose of the Study:
- To evaluate the efficacy of inhaled indomethacin in mitigating exercise-induced bronchoconstriction (EIB) in pediatric asthma patients.
- To assess the impact of inhaled indomethacin on lung function and arterial oxygen saturation following exercise challenges.
Main Methods:
- A double-blind, randomized, crossover study involving nine children with asthma and a history of EIB.
- Participants received either inhaled indomethacin (3 mg/m2 BSA) or placebo (0.9% saline) 15 minutes before an exercise challenge test.
- Lung function (FEV1) and arterial oxygen saturation were measured post-exercise.
Main Results:
- Inhaled indomethacin significantly attenuated EIB, reducing the maximal percent decrease in FEV1 from 36.1% with placebo to 18.0% with indomethacin (p = 0.0310).
- Indomethacin also significantly reduced the maximal decrease in arterial oxygen saturation after exercise (p = 0.0378).
Conclusions:
- Inhaled indomethacin demonstrates a protective effect against exercise-induced bronchoconstriction in children with asthma.
- The mechanism may involve the inhibition of local prostaglandin synthesis and/or airway ion transport.
Abstract:
We evaluated the effect of inhaled indomethacin, a nonsteroidal antiinflammatory drug (NSAID), on exercise-induced bronchoconstriction (EIB) in children with asthma. Nine asthmatic children (7 boys, 2 girls, with a mean +/- SEM age of 11.0 +/- 0.8 yr) with a history of EIB participated in this study. These subjects were pretreated with inhaled indomethacin (3 mg/m2 body surface area [BSA]) or placebo (0.9% saline) according to a double-blind, randomized, crossover design, and underwent an exercise challenge test 15 min after the pretreatment. Inhaled indomethacin significantly attenuated EIB. The mean maximal percent decrease in FEV1 following exercise was 36.1 +/- 5.7% after placebo and 18.0 +/- 4.6% after indomethacin pretreatment (p = 0.0310). Indomethacin also significantly reduced the mean maximal decrease in arterial oxygen saturation after exercise (p = 0.0378). The inhibition of local prostaglandin synthesis and/or ion transport in the airways may be a mechanism involved in the protective potency of inhaled indomethacin.