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Chronic renal vein thrombosis

R Cade, G Spooner, L Juncos

    The American Journal of Medicine
    |September 1, 1977
    PubMed
    Summary

    Chronic renal vein thrombosis can be diagnosed by a specific set of symptoms, including nephrotic syndrome and pulmonary embolization. Anticoagulant therapy proved effective for managing this condition.

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    Area of Science:

    • Nephrology
    • Vascular Medicine

    Background:

    • Chronic renal vein thrombosis (CRVT) is a significant condition affecting renal vasculature.
    • Understanding the clinical manifestations of CRVT is crucial for timely diagnosis and management.

    Purpose of the Study:

    • To identify a diagnostic constellation of clinical findings associated with chronic renal vein thrombosis.
    • To evaluate the effectiveness of anticoagulant therapy in patients with CRVT.

    Main Methods:

    • Study included 28 patients with confirmed chronic renal vein thrombosis.
    • Clinical findings, laboratory results, and treatment outcomes were analyzed.

    Main Results:

    • A specific set of findings, including nephrotic syndrome, variable proteinuria, altered glomerular filtration rate, pulmonary embolization, sterile pyuria, hematuria, hyperchloremic acidosis, decreased renal tubular glucose threshold, and increased fibrin degradation products, were frequently observed.

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  • These findings were deemed virtually diagnostic of renal venous obstruction.
  • Angiographic and biopsy procedures were indicated for definitive diagnosis.
  • Prolonged anticoagulant therapy was generally effective.

    • Conclusions:

    • A distinct clinical presentation strongly suggests chronic renal vein thrombosis.
    • Early diagnosis through characteristic findings facilitates appropriate intervention.
    • Anticoagulant therapy is a viable and effective treatment for CRVT.