Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dendritic cells presenting tumor antigen

M R Shurin1

  • 1University of Pittsburgh Cancer Institute, Division of Biological Therapeutics, PA 15213, USA.

Cancer Immunology, Immunotherapy : CII
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ChemoImmunoModulation: immune regulation by the antineoplastic chemotherapeutic agents.

Current medicinal chemistry·2012
Same author

Comparative analysis of CD1a, S-100, CD83, and CD11c human dendritic cells in normal, premalignant, and malignant tissues.

Histology and histopathology·2005
Same author

Human renal cell carcinoma inhibits dendritic cell maturation and functions.

Der Urologe. Ausg. A·2004
Same author

TNF-alpha protects dendritic cells from prostate cancer-induced apoptosis.

Prostate cancer and prostatic diseases·2002
Same author

Mechanisms of dendritic cell-induced T cell proliferation in the primary MLR assay.

Immunology letters·2001
Same author

Identification of delta- and mu-type opioid receptors on human and murine dendritic cells.

Journal of neuroimmunology·2001

Dendritic cells are key antigen-presenting cells (APCs) that initiate immune responses and tolerance. Research highlights their crucial role in antitumor immunity, utilizing antigen presentation to stimulate T cells for therapeutic benefits.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) were first identified in 1973.
  • DCs are critical antigen-presenting cells (APCs) that initiate immune responses and tolerance.
  • Their biology encompasses cell culture, migration, maturation, and regulation by cytokines and accessory molecules.

Purpose of the Study:

  • To review key aspects of dendritic cell biology.
  • To discuss the role of dendritic cells in antitumor immunity.
  • To highlight studies demonstrating dendritic cell-mediated antigen presentation for immune stimulation.

Main Methods:

  • Review of existing literature on dendritic cell biology and function.
  • Analysis of studies investigating dendritic cell-mediated antigen presentation.
  • Examination of in vitro and in vivo experimental evidence.

Related Experiment Videos

Main Results:

  • Dendritic cells acquire, process, and present antigens to T cells in lymphoid tissues.
  • Antigen-pulsed dendritic cells can sensitize T cells and induce antigen-specific immune responses.
  • Evidence supports the role of dendritic cells in both protective and therapeutic antitumor immunity.

Conclusions:

  • Dendritic cells are professional APCs essential for initiating adaptive immunity.
  • Their function in antigen presentation is vital for developing antitumor immune responses.
  • Further understanding of dendritic cell biology can advance cancer immunotherapy.