Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacokinetics and renal function in preterm infants

J N van den Anker1

  • 1Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands.

Acta Paediatrica (Oslo, Norway : 1992)
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: "Simultaneous Pharmacokinetic Modeling of Gentamicin, Tobramycin and Vancomycin Clearance From Neonates to Adults: Towards a Semi-physiological Function for Maturation in Glomerular Filtration".

Pharmaceutical research·2025
Same author

Therapeutic Drug Monitoring in Neonates: What Makes them Unique?

Current pharmaceutical design·2017
Same author

Possible effects of repeated exposure to ibuprofen and acetaminophen on the intestinal immune response in young infants.

Medical hypotheses·2015
Same author

Sildenafil and retinopathy of prematurity risk in very low birth weight infants.

Journal of perinatology : official journal of the California Perinatal Association·2015
Same author

Emerging biomarkers and metabolomics for assessing toxic nephropathy and acute kidney injury (AKI) in neonatology.

BioMed research international·2014
Same author

Optimising the management of fever and pain in children.

International journal of clinical practice. Supplement·2012

Advances in neonatal care improve preterm infant survival. However, optimizing drug therapy (pharmacotherapy) requires understanding how organ maturation affects drug processing and elimination in these vulnerable infants.

Area of Science:

  • Neonatal Medicine
  • Developmental Pharmacology
  • Clinical Pharmacokinetics

Background:

  • Improving survival rates in preterm infants necessitates advancements in pharmacotherapy.
  • Understanding drug pharmacokinetics in neonates is crucial for safe and effective treatment.
  • Developmental changes in organ systems significantly impact drug disposition.

Purpose of the Study:

  • To review the impact of maturational changes on renal function in preterm infants.
  • To analyze how these changes affect clinical pharmacokinetics.
  • To highlight the importance of understanding ontogeny in neonatal drug therapy.

Main Methods:

  • Literature review focusing on human developmental biology.
  • Analysis of studies on drug absorption, disposition, metabolism, and excretion in neonates.

Related Experiment Videos

  • Examination of the effects of renal function maturation on drug pharmacokinetics.

    • Main Results:

    • Organ system maturation and body composition changes significantly alter drug disposition in preterm infants.
    • Renal function maturation is a key factor influencing drug pharmacokinetics.
    • Drug-induced changes in renal function can further complicate pharmacotherapy.

    Conclusions:

    • Effective pharmacotherapy in preterm infants demands a deep understanding of developmental physiology.
    • Maturation of renal function critically impacts drug efficacy and safety.
    • Further research is needed to optimize drug dosing and administration in this population.