Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transient hypertriglyceridemia of infancy

A Nilsson1, E Ortqvist, H Lagercrantz

  • 1Department of Paediatrics, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|December 1, 1996
PubMed
Summary

A premature infant experienced severe hypertriglyceridemia due to decreased lipoprotein lipase (LPL) activity. This condition resolved spontaneously, suggesting a partial genetic LPL deficiency as the likely cause.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How carbon monoxide adsorbs in different sites.

Physical review letters·2000
Same author

Alkaline sphingomyelinases and ceramidases of the gastrointestinal tract.

Chemistry and physics of lipids·2000
Same author

Wheezing following lower respiratory tract infections with respiratory syncytial virus and influenza A in infancy.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2000
Same author

Allopurinol in addition to 5-aminosalicylic acid based drugs for the maintenance treatment of ulcerative colitis.

Alimentary pharmacology & therapeutics·2000
Same author

Partitioning of peptides and recombinant protein-peptide fusions in thermoseparating aqueous two-phase systems: effect of peptide primary structure.

Journal of chromatography. B, Biomedical sciences and applications·2000
Same author

Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries.

Nature biotechnology·2000

Area of Science:

  • Biochemistry
  • Pediatrics
  • Genetics

Background:

  • Premature infants are susceptible to various health complications.
  • Infant respiratory distress syndrome (IRDS), bronchopulmonary dysplasia, and retinopathy of prematurity are common in premature infants.
  • Hyperlipidemia can occur in infants, necessitating investigation into its underlying causes.

Observation:

  • A 5-month-old premature boy with a history of IRDS, bronchopulmonary dysplasia, and retinopathy of prematurity presented with massive hypertriglyceridemia (48.1 mmol/L) and moderate hypercholesterolemia (12.6 mmol/L).
  • Lipoprotein electrophoresis showed elevated very-low-density lipoprotein levels.
  • A moderate decrease in lipoprotein lipase (LPL) activity was observed.
  • The child had no liver or renal disorders or inflammatory conditions.

Related Experiment Videos

Findings:

  • The infant exhibited severe hypertriglyceridemia and hypercholesterolemia.
  • Reduced lipoprotein lipase (LPL) activity was identified as a key factor.
  • The hyperlipidemia resolved spontaneously by age 3 years.
  • No secondary causes for decreased LPL activity were identified.

Implications:

  • The findings suggest a potential partial genetic deficiency in lipoprotein lipase (LPL) as the cause of severe hypertriglyceridemia in this infant.
  • This case highlights the importance of considering genetic factors in pediatric hyperlipidemia, even in the absence of secondary causes.
  • Further research into genetic LPL deficiencies in pediatric populations may be warranted.