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Published on: June 2, 2014
Sumatriptan and lost productivity time: a time series analysis of diary data
D W Miller1, B C Martin, C M Loo
1Glaxo Wellcome Research and Development, Greenford, Middlesex, UK.
Clinical Therapeutics
|November 1, 1996
Summary
Sumatriptan treatment significantly reduced migraine-related lost nonworkplace activity time and workplace productivity time. These productivity gains were sustained and not due to natural data trends or regression to the mean.
Area of Science:
- Neurology
- Pharmacology
- Health Economics
Background:
- Migraine significantly impacts daily life, causing substantial lost nonworkplace activity and workplace productivity time.
- Previous studies indicated sumatriptan use reduced these losses, but statistical methods couldn't rule out data trends.
Purpose of the Study:
- To rigorously assess the impact of sumatriptan on migraine-related productivity losses using time series analysis.
- To determine if observed productivity gains were attributable to sumatriptan treatment or other factors like time trends.
Main Methods:
- Time series analysis was employed to analyze data from two prior clinical studies.
- Linear models were computed to detect and control for preexisting trends in lost activity and productivity time.
Main Results:
- Sumatriptan initiation resulted in an average weekly saving of 0.8 hours of nonworkplace activity and 0.5 hours of workplace productivity per patient.
- These savings remained consistent throughout the sumatriptan treatment period.
- No significant preexisting trends or regression to the mean effects were detected.
Conclusions:
- Sumatriptan therapy is associated with significant and sustained reductions in migraine-related productivity losses.
- The observed productivity gains are directly attributable to sumatriptan management, not confounding statistical factors.
