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Updated: Aug 8, 2026
Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
Published on: June 6, 2011
Failure of dobutamine to improve liver oxygenation during resuscitation with a crystalloid solution after
A J Nordin1, H Mäkisalo, K A Höckerstedt
1Fourth Department of Surgery, Helsinki University Hospital, Finland.
Objective:
To evaluate the effects of dobutamine on peripheral and hepatic tissue oxygen tensions during the treatment of haemorrhagic shock.
Design:
Randomised, controlled trial.
Setting:
University hospital, Finland.
Subjects:
12 Piglets, weight 20 kg.
Interventions:
Haemorrhagic shock (40% of blood volume removed) and resuscitation with crystalloid solution. Dobutamine infused (6.5 micrograms/kg/min) during resuscitation in 6 animals and 6 served as controls.
Main Outcome Measures:
Haemodynamic and systemic oxygen transport variables. Hepatic, subcutaneous, transcutaneous, and conjunctival oxygen tensions measured continuously with polarographic electrodes.
Results:
All values decreased significantly during bleeding. Resuscitation restored the mean arterial pressure in both groups, and cardiac output exceeded the baseline by 24% in the dobutamine group (p < 0.05 compared with control). There was no difference in oxygen delivery and consequently tissue oxygen tensions remained at the control level in the dobutamine group.
Conclusions:
Dobutamine infusion did not improve tissue oxygenation when used in addition to crystalloids to treat hypovolaemic shock.
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