Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunotherapy of leprosy

K Katoch1

  • 1Central JALMA Institute for Leprosy (ICMR), Tajganj, Agra.

Indian Journal of Leprosy
|October 1, 1996
PubMed
Summary

Immunotherapy using mycobacterial agents and other immunomodulators shows promise in enhancing bacterial killing and clearance for leprosy patients. This approach may shorten treatment duration, especially for those with high bacterial loads.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sub-national TB prevalence surveys in India, 2006-2012: Results of uniformly conducted data analysis.

PloS one·2019
Same author

Rapid detection of ethambutol-resistant <i>Mycobacterium tuberculosis</i> in clinical specimens by real-time polymerase chain reaction hybridisation probe method.

Indian journal of medical microbiology·2018
Same author

Addition of Mycobacterium indicus pranii vaccine as an immunotherapeutic to standard chemotherapy in borderline leprosy: a double-blind study to assess clinical improvement (preliminary report).

The British journal of dermatology·2016
Same author

Human immunodeficiency virus and hepatitis B virus co-infections among tuberculosis patients attending a Model Rural Health Research Unit in Ghatampur, North India.

Indian journal of medical microbiology·2015
Same author

Evaluation of the diagnostic value of immunocytochemistry and in situ hybridization in the pediatric leprosy.

Indian journal of leprosy·2014
Same author

Clinical and histopathological evaluation of the effect of addition of immunotherapy with Mw vaccine to standard chemotherapy in borderline leprosy.

Indian journal of leprosy·2013

Area of Science:

  • Immunology
  • Microbiology
  • Dermatology

Background:

  • Leprosy involves a defective cell-mediated immune response in some patients.
  • Current treatments can be lengthy, particularly for bacilliferous cases.

Purpose of the Study:

  • To review immunomodulators investigated for enhancing immune response in leprosy.
  • To assess the potential of immunotherapy as an adjunct to standard chemotherapy.

Main Methods:

  • Review of various mycobacterial agents (e.g., BCG, Mycobacterium w) and other immunomodulators (e.g., levamisole, interferon gamma).
  • Analysis of studies investigating the effects of these agents on bacterial killing and clearance in leprosy patients.

Main Results:

  • Mycobacterial agents like BCG, Mycobacterium w, ICRC bacillus, and M. vaccae demonstrated beneficial effects on bacterial clearance.
  • Other agents including levamisole, zinc, transfer factor, interferon gamma, and interleukin 2 also showed immunomodulatory roles.
  • Experimental studies indicated promise for other mycobacteria (M. habana, M. phlei, M. gordonae).

Conclusions:

  • Immunotherapy can serve as an effective adjunct to chemotherapy in leprosy treatment.
  • Enhancing bacterial killing and clearance through immunotherapy may significantly shorten treatment periods.
  • This is particularly relevant for bacilliferous leprosy cases, improving patient outcomes.

Related Experiment Videos