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Potential impact of altitude on lung function

C Wolf1, A Staudenherz, G Röggla

  • 1Department of Occupational Medicine, University of Vienna, Austria. chris.wolf@univie.ac.at

International Archives of Occupational and Environmental Health
|January 1, 1997
PubMed
Summary

Higher altitudes significantly impact specific lung function measurements. Mean expiratory flows (MEF75 and MEF50) increased with altitude, suggesting altered airflow dynamics.

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Area of Science:

  • Pulmonary Physiology
  • Environmental Medicine

Background:

  • Lung function can be influenced by environmental factors.
  • Understanding these influences is crucial for accurate physiological assessments.

Purpose of the Study:

  • To evaluate the impact of varying altitudes on lung function parameters.
  • To identify specific spirometric measures affected by altitude.

Main Methods:

  • Twenty-one healthy volunteers participated in the study.
  • Spirometry was performed at two altitudes: 171 m and 1580 m.
  • Measurements included forced vital capacity (FVC), forced expiration volume after 1 s (FEV1), and various expiratory flow rates (MEF75, MEF50, MEF25, PEF).

Main Results:

  • Mean expiratory flow at 75% (MEF75) and 50% (MEF50) of FVC showed a positive correlation with altitude.

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  • MEF75 increased by 15% and MEF50 by 11% at higher altitudes, with statistically significant differences (P = 0.0009 and P = 0.0001, respectively).
  • Other spirometric parameters like FVC, FEV1, FEV1/FVC, MEF25, and PEF did not show significant changes.

    • Conclusions:

    • Altitude is a significant variable affecting spirometric measurements.
    • Specific parameters, particularly MEF75 and MEF50, are sensitive to changes in altitude.