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Related Experiment Videos

Use of ciprofloxacin in developing countries

S Green1, G Tillotson

  • 1St. Luke's Hospital, Bradford, Yorkshire, United Kingdom.

The Pediatric Infectious Disease Journal
|January 1, 1997
PubMed
Summary

Ciprofloxacin is a safe and effective antibiotic for treating pediatric infections in developing nations, addressing rising antibiotic resistance. Its use is crucial as other treatment options diminish.

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Area of Science:

  • Infectious Diseases
  • Pediatric Medicine
  • Antimicrobial Resistance

Background:

  • Rising antibiotic resistance in developing nations due to demographic and economic pressures.
  • Diminishing empirical treatment options for pediatric infections.
  • Increasing significance of ciprofloxacin for pediatric infections.

Purpose of the Study:

  • Describe resistance levels in enteric pathogens.
  • Evaluate ciprofloxacin's efficacy and safety in pediatric infections (shigellosis, cholera, E. coli gastroenteritis).
  • Present findings on invasive salmonellosis and meningococcal disease chemoprophylaxis.

Main Methods:

  • Review of existing studies on ciprofloxacin efficacy and safety in children.
  • Analysis of resistance patterns in enteric pathogens.
  • Inclusion of data from a large study on invasive salmonellosis in African children.

Main Results:

  • Ciprofloxacin demonstrated comparable efficacy and safety in children to adults for gastrointestinal infections.
  • Confirmed ciprofloxacin as a safe and effective treatment for pediatric infections in developing countries.
  • Highlighted ciprofloxacin's role in managing multidrug-resistant invasive diseases.

Conclusions:

  • Ciprofloxacin is a safe and effective therapeutic option for children in developing countries.
  • Urgent need to prevent fluoroquinolone misuse and curb antibiotic resistance development.
  • Prioritization for pharmaceutical industry and regulatory bodies in developing nations.

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