Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Elevated plasma basic fibroblast growth factor in brain tumor patients

M Kurimoto¹, S Endo, Y Hirashima

¹Department of Neurosurgery, Toyama Medical and Pharmaceutical University.

Neurologia Medico-Chirurgica

|December 1, 1996

Summary

Elevated plasma levels of basic fibroblast growth factor (bFGF) were found in many brain tumor patients, particularly those with malignant gliomas. Further research is needed to confirm bFGF as a diagnostic marker for brain tumors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Treatment of an arteriovenous shunt draining into a venous angioma by selective embolisation. A case report.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010

Same author

Pitfalls in endovascular treatment of dural arteriovenous fistulas involving the cavernous sinus.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010

Same author

Treatment of intracranial (dural) arteriovenous fistulas in unusual locations.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010

Same author

Clinico-pathological study in patients with transverse-sigmoid sinus dural arteriovenous malformations.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2008

Same author

Sequential changes and recoveries of the motor evoked potential in experimental hypertension.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2008

Same author

Cerebrospinal fluid membrane-bound tissue factor and myelin basic protein in the course of vasospasm after subarachnoid hemorrhage.

Neurological research·2001

Area of Science:

Oncology
Biochemistry
Neuroscience

Background:

Basic fibroblast growth factor (bFGF) is implicated in cell growth and angiogenesis.
Brain tumors represent a significant health concern with ongoing research into diagnostic markers.

Purpose of the Study:

To investigate if plasma concentrations of bFGF are elevated in patients with brain tumors.
To explore the potential of bFGF as a diagnostic or prognostic marker for brain tumors.

Main Methods:

Plasma bFGF levels were quantified using enzyme immunoassay.
Measurements were taken from 55 brain tumor patients and 17 healthy individuals.
Correlation between bFGF levels and tumor volume was analyzed.

Main Results:

Related Experiment Videos

The normal upper limit for plasma bFGF was established at 1.6 pg/ml.
Elevated bFGF levels were detected in 28 out of 55 brain tumor patients.
Significantly higher bFGF levels were observed in malignant glioma patients (12 of 14).
A positive correlation was found between elevated bFGF and tumor volume (r = 0.42, p < 0.05).

Conclusions:

Plasma bFGF levels may be elevated in patients with brain tumors, especially malignant gliomas.
The correlation with tumor volume suggests a potential role in tumor progression.
Further investigation is warranted to establish clinical utility as a diagnostic and prognostic biomarker.