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Updated: Aug 10, 2026

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
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Published on: January 12, 2013

SPECT imaging with 111In-octreotide for the localization of pancreatic insulinoma

A Signore1, E Procaccini, M Chianelli

  • 1Special Service of Nuclear Medicine, II Medical Clinic, University La Sapienza, Rome, Italy.

The Quarterly Journal of Nuclear Medicine : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR)
|December 1, 1995
PubMed

We evaluated the sensitivity of 111In-Octreotide scintigraphy in the diagnosis of pancreatic insulinoma in a selected number of patients. In addition, we compared the results of scintigraphy with those of other conventional diagnostic techniques. Seven patients with surgically confirmed insulinoma (< 1.5 cm in diameter) of the pancreas were studied. Before surgery, patients underwent arteriography with Ca-gluconate, CT scan, and 111In-Octreotide scintigraphy. 111In-Octreotide scintigraphy showed a higher diagnostic specificity (85%) than selective arteriography (83%) or CT scan (57%). We conclude that 111In-Octreotide scintigraphy should always be performed before surgery in cases of pancreatic insulinoma and that a SPECT acquisition should be performed both 6 and 24 hours post-injection in order to increase the diagnostic sensitivity of the test.

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