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Related Experiment Videos

99mTc-2GAM: a tracer for renal imaging

L Gianolli1, F Dosio, M Matarrese

  • 1INB-CNR, University of Milan, Department of Nuclear Medicine, H San Raffaele, Italy.

Nuclear Medicine and Biology
|November 1, 1996
PubMed
Summary

A new renal imaging agent, 99mTc-2GAM, offers faster kidney uptake than 99mTc-DMSA. This technetium-99m complex shows excellent biodistribution and dosimetric features for effective renal imaging.

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Area of Science:

  • Nuclear Medicine
  • Radiopharmaceutical Chemistry

Background:

  • Renal imaging agents are crucial for diagnosing kidney diseases.
  • Technetium-99m dimercaptosuccinic acid (99mTc-DMSA) is a standard agent but has limitations.
  • There is a need for agents with improved pharmacokinetic profiles for renal imaging.

Purpose of the Study:

  • To develop and evaluate a novel renal imaging agent, 99mTc-2GAM.
  • To assess the biodistribution, toxicity, and imaging characteristics of 99mTc-2GAM in preclinical and clinical studies.
  • To compare the performance of 99mTc-2GAM with 99mTc-DMSA for renal imaging.

Main Methods:

  • Synthesis and characterization of the 99mTc complex of N-(mercaptoacetyl)glycine (99mTc-2GAM).
  • Biodistribution and toxicity studies in animal models.

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  • Clinical evaluation in five normal volunteers, including dynamic imaging and blood clearance measurements.
  • Comparative study with 99mTc-DMSA in three patients with unilateral kidney disease.

    • Main Results:

    • 99mTc-2GAM demonstrated rapid blood clearance (t1/2 = 9 min) and efficient urinary excretion.
    • High renal uptake (11.3%–20.7% ID) was observed, increasing up to 1 hour with minimal washout.
    • Low, stable liver uptake and negligible uptake in other organs were noted.
    • No significant differences in imaging findings were observed between 99mTc-2GAM and 99mTc-DMSA in patients with unilateral kidney disease.

    Conclusions:

    • 99mTc-2GAM exhibits favorable pharmacokinetic and dosimetric properties for renal imaging.
    • The agent shows rapid uptake and retention in the kidneys, making it suitable for dynamic and static imaging.
    • 99mTc-2GAM represents a promising alternative or adjunct to 99mTc-DMSA for evaluating renal function and morphology.