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Related Experiment Videos

A diacetylmorphine polymorph

J R Deschamps1, C George, J L Flippen-Anderson

  • 1Laboratory for the Structure of Matter, Naval Research Laboratory, Washington, DC 20375, USA. deschamp@medusa.nrl.navy.mil

Acta Crystallographica. Section C, Crystal Structure Communications
|March 15, 1996
PubMed
Summary
This summary is machine-generated.

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Crystallographic analysis of 7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diyl diacetate revealed new crystal structures. Unlike previous hexagonal orthorhombic findings, this study identified monoclinic crystals in space group P2(1).

Area of Science:

  • Crystallography
  • Organic Chemistry
  • Pharmacology

Background:

  • The title compound, 7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diyl diacetate, is a derivative of morphinan alkaloids.
  • Previous crystallographic studies reported hexagonal (orthorhombic) crystal forms with space group P2(1)2(1)2(1).

Purpose of the Study:

  • To determine the crystal structure of 7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diyl diacetate.
  • To compare the obtained crystal structure with previously reported findings.

Main Methods:

  • Crystallization of the title compound from a solution of its hydrochloride and sodium acetate.
  • Single-crystal X-ray diffraction analysis to determine unit cell parameters and space group.

Main Results:

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  • The compound crystallized as large prisms, indicating a monoclinic crystal system.
  • The determined space group was P2(1), differing from the previously reported P2(1)2(1)2(1).

Conclusions:

  • The crystallographic properties of 7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diyl diacetate have been elucidated.
  • This study presents a novel monoclinic crystal form (space group P2(1)) distinct from prior orthorhombic reports.