Related Experiment Video

Updated: Jun 29, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

[Changes in the indices of left ventricular filling in elderly patients with ischemic heart disease]

O V Korkushko, G Z Moroz, I N Gidzinskaia

    Likars'Ka Sprava
    |January 1, 1996
    PubMed

    Insights

    Elderly patients with ischemic heart disease show altered left ventricular filling patterns, particularly in early filling phases. Age significantly impacts early filling dynamics, with specific changes observed in patients with exertional angina.

    Area of Science:

    • Cardiology
    • Gerontology
    • Medical Imaging

    Background:

    • Left ventricular (LV) filling is crucial for cardiac function.
    • Aging affects cardiovascular physiology.
    • Ischemic heart disease (IHD) can alter LV diastolic function.

    Purpose of the Study:

    • To investigate age-related changes in LV filling.
    • To compare LV filling characteristics between healthy elderly individuals and elderly patients with IHD.

    Main Methods:

    • Echocardiography was used to assess LV filling in three groups: young healthy adults, elderly healthy adults, and elderly IHD patients.
    • Echocardiograms were processed using computer analysis.
    • 20 subjects were included in each group.

    Main Results:

    • The early filling phase showed the most significant age-related changes.
    • IHD patients exhibited prolonged atrial systole and shortened total filling time.
    • A reduced ratio of slow filling duration to fast filling duration was observed in IHD patients.
    • Increased volume rate of blood filling during the slow filling phase was noted in IHD patients.

    Conclusions:

    • Aging significantly impacts the early phase of left ventricular filling.
    • Elderly patients with ischemic heart disease demonstrate distinct diastolic dysfunction patterns compared to healthy controls.
    • Echocardiography is a valuable tool for characterizing LV filling abnormalities in IHD.

    More Related Videos

    Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery08:17

    Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

    Published on: February 20, 2017

    Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery04:48

    Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

    Published on: November 28, 2018

    Related Concept Videos

    Imbalances in Cardiac Output01:26

    Imbalances in Cardiac Output

    The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
    CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
    Imaging Studies for Cardiovascular System III: X-Ray01:20

    Imaging Studies for Cardiovascular System III: X-Ray

    The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
    Definition and Purpose
    An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
    Mitral Stenosis I: Introduction01:22

    Mitral Stenosis I: Introduction

    Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
    Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

    Aortic Regurgitation II: Clinical Features and Diagnostic Tests

    Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
    Heart Failure II: Pathophysiology01:29

    Heart Failure II: Pathophysiology

    Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
    Heart Failure III: Clinical Manifestations01:26

    Heart Failure III: Clinical Manifestations

    Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...