Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hormone replacement therapy and cardiovascular risk]

S Maffei1, R De Caterina

  • 1Laboratorio per lo Studio della Trombosi e dell'Aterosclerosi, C.N.R, Pisa.

Giornale Italiano Di Cardiologia
|August 1, 1996
PubMed
Summary

Hormone replacement therapy may protect post-menopausal women from coronary artery disease by favorably affecting lipid profiles and the vascular system. However, risks and benefits require personalized evaluation due to limited long-term data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exercise pulmonary hypertension in asymptomatic patients with HIV infection Insights from the RIGHT-NET registry.

European journal of internal medicine·2026
Same author

Baseline clinical profile of patients with obstructive hypertrophic cardiomyopathy in the Italian Mavacamten early access program.

International journal of cardiology·2026
Same author

Efficacy of mechanical thrombectomy in patients with ischemic stroke and cancer.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2021
Same author

Characteristics of patients with atrial fibrillation prescribed edoxaban in Belgium and the Netherlands: insights from the ETNA-AF-Europe study.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2021
Same author

Impaired adenylate cyclase signaling in acute myocardial ischemia: Impact on effectiveness of P2Y<sub>12</sub> receptor antagonists.

Thrombosis research·2019
Same author

Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study.

International journal of endocrinology·2019

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Women's Health

Background:

  • Coronary artery disease (CAD) is a leading cause of death globally, with notable sex differences in incidence.
  • Fertile women exhibit relative protection against CAD, which diminishes post-menopause, suggesting hormonal influence.

Purpose of the Study:

  • To review the effects of hormone replacement therapy (HRT) on cardiovascular risk in post-menopausal women.
  • To explore the potential mechanisms underlying HRT's cardiovascular effects.
  • To highlight areas of ongoing research and clinical considerations.

Main Methods:

  • Review of epidemiological and observational studies on HRT and cardiovascular outcomes.
  • Analysis of evidence regarding estrogen's impact on lipid profiles, vessel wall biology, and atherosclerosis.
  • Identification of active research areas, including molecular mechanisms and metabolic effects.

Main Results:

  • Estrogens show protective effects on cardiovascular health, improving lipid profiles (lowering LDL, increasing HDL) and benefiting the vessel wall.
  • HRT may influence vascular response, endothelial and smooth muscle cell function, hemostasis, and glucose metabolism.
  • Lack of prospective studies on hard endpoints (mortality, morbidity) and ongoing debate regarding risks like breast cancer.

Conclusions:

  • HRT offers potential cardiovascular benefits for post-menopausal women, primarily through estrogenic effects.
  • Further research is needed to confirm effects on hard clinical endpoints and fully elucidate risks.
  • Treatment decisions for HRT must be individualized, carefully weighing potential benefits against risks.

Related Experiment Videos