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Multinucleate ameloblasts in the rat incisor

C E Smith, H Warshawsky

    The Anatomical Record
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Multinucleate ameloblasts, cells with multiple nuclei, were observed in rat incisor enamel. These multinucleated cells increase with ameloblast age, suggesting cell fusion as the likely origin.

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    Area of Science:

    • Dental Biology
    • Cell Biology
    • Histology

    Background:

    • Ameloblasts are crucial for enamel formation.
    • The cellular dynamics of amelogenesis are not fully understood.
    • Multinucleation in ameloblasts has been infrequently reported.

    Purpose of the Study:

    • To investigate the occurrence and characteristics of multinucleate ameloblasts.
    • To determine the prevalence and distribution of multinucleate ameloblasts during amelogenesis.
    • To elucidate the potential origin of multinucleate ameloblasts.

    Main Methods:

    • Light and electron microscopy of rat incisor enamel organ.
    • 3H-thymidine labeling in vivo.
    • Quantitative nuclear counting in different amelogenesis zones.

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    Main Results:

    • Identified ameloblasts with 2-3+ nuclei, typically with vertically apposed nuclei.
    • Electron microscopy showed no nuclear connections; 3H-thymidine labeling indicated nuclear-specific incorporation.
    • Multinucleate ameloblasts were 60x more frequent in the maturation zone and increased with maturation stage.

    Conclusions:

    • Multinucleate ameloblasts are more prevalent in older ameloblasts.
    • Cell fusion is the probable mechanism for multinucleate ameloblast formation.
    • Multinucleation is associated with the maturation stage of amelogenesis.