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Mitochondrial function in muscle from elderly athletes

E J Brierly1, M A Johnson, A Bowman

  • 1Department of Neurology, Medical School, University of Newcastle upon Tyne, UK.

Annals of Neurology
|January 1, 1997
PubMed
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Mitochondria function does not decline with age in athletes. This suggests that cellular aging may involve more complex mechanisms than a simple decrease in mitochondrial respiratory chain activity.

Area of Science:

  • Gerontology
  • Mitochondrial biology
  • Skeletal muscle physiology

Background:

  • Mitochondrial involvement in aging is debated.
  • Reported declines in mitochondrial function may stem from disease or inactivity, not aging itself.

Purpose of the Study:

  • To investigate the true impact of aging on mitochondrial respiratory chain function.
  • To differentiate age-related changes from disease or inactivity effects in skeletal muscle.

Main Methods:

  • Studied mitochondrial respiratory chain function.
  • Compared young athletes (n=9) and elderly athletes (n=12).

Main Results:

  • No significant age-related deterioration in mitochondrial function was observed.

Related Experiment Videos

  • Elderly athletes maintained mitochondrial respiratory chain activity comparable to younger athletes.

    • Conclusions:

    • Aging does not necessarily cause a global decline in skeletal muscle mitochondrial respiratory chain activity.
    • Mitochondrial roles in aging, if any, likely involve more subtle mechanisms than a broad decrease in function.