Related Experiment Videos
Hypercoagulability and hypofibrinolysis in primary osteoarthritis
P A Cheras1, A N Whitaker, E A Blackwell
1Arthritis Research Group, Department of Surgery, The University of Queensland, Greenslopes Private Hospital, Australia.
Clinical Orthopaedics and Related Research
|January 1, 1997
Summary
Osteoarthritis patients exhibit a prothrombotic state with impaired fibrinolysis and abnormal lipid levels. This suggests a link between coagulation, lipids, and the progression of osteoarthritis.
Area of Science:
- Biochemistry
- Hematology
- Orthopedics
Background:
- Venous thrombosis and lipid abnormalities are observed in osteoarthritis.
- Hypofibrinolysis is implicated in osteonecrosis.
- The systemic coagulation and lipid profiles in osteoarthritis require further investigation.
Purpose of the Study:
- To investigate systemic coagulation and lipid abnormalities in patients with degenerative osteoarthritis of the hip.
- To determine if a hypercoagulable and prothrombotic state exists in osteoarthritis.
- To explore the role of hypofibrinolysis and lipid abnormalities in osteoarthritis pathogenesis.
Main Methods:
- Coagulation and fibrinolysis assessed using global and specific tests.
- Platelet sensitivity evaluated across adenosine diphosphate concentrations.
- Lipid profiles (cholesterol, LDL, triglycerides) analyzed.
- Comparison between 44 osteoarthritis patients and 52 matched controls.
Main Results:
- Osteoarthritis patients showed increased factor VIIlc, heightened platelet sensitivity, and elevated D dimer levels.
- Prolonged euglobulin clot lysis time and increased plasminogen activator inhibitor Type 1 activity indicated hypofibrinolysis.
- Relative hyperlipidemia observed, with increased cholesterol, LDL cholesterol, and triglyceride levels.
Conclusions:
- A hypercoagulable and prothrombotic condition is present in osteoarthritis.
- Hypofibrinolysis and increased fibrin generation are evident in osteoarthritis patients.
- Lipid abnormalities may contribute to hemostatic imbalance in osteoarthritis.