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The human dander atopy. I. The prototype of auto-atopy
Annals of Allergy
|September 1, 1977
Summary
Human dander is a significant allergen causing skin reactions in atopic individuals. This study suggests human dander may be an autoallergen, with potential for more autoallergens triggering allergic responses.
Area of Science:
- Allergen research
- Immunology
- Dermatology
Background:
- Human dander is recognized as a potential allergen.
- Atopic patients frequently exhibit skin reactions to environmental allergens.
- The role of autoallergens in atopic conditions requires further investigation.
Purpose of the Study:
- To investigate the allergenic potential of human dander.
- To discuss the clinical significance of human dander allergy.
- To explore the possibility of human dander acting as an autoallergen.
Main Methods:
- Clinical data collection from patients with atopic dermatitis.
- Allergenicity testing for human dander.
- Immunological analysis of IgE-type antibodies.
Main Results:
- Human dander was confirmed as a true allergen.
- Skin reactions were most common in atopic patients exposed to human dander.
- A cohort of patients exclusively atopic to human dander was identified.
Conclusions:
- Human dander is a clinically relevant allergen.
- Human dander is likely an autoallergen.
- The atopic organism may produce IgE-type antibodies to multiple autoallergens.