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Phenformin-associated pancreatitis

H S Chase, G R Mogan

    Annals of Internal Medicine
    |September 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Phenformin, a diabetes medication, may be linked to acute pancreatitis and lactic acidosis. This case report and literature review highlight this rare but serious adverse drug reaction.

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    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Pharmacology

    Background:

    • Phenformin is an antidiabetic medication.
    • Phenformin has been anecdotally linked to acute pancreatitis.
    • The association between phenformin and pancreatitis requires further investigation.

    Observation:

    • A 70-year-old male with diabetes developed acute hemorrhagic pancreatitis and severe lactic acidosis.
    • The patient was taking phenformin and no other medications.
    • No other risk factors for pancreatitis were identified.

    Findings:

    • This case and a review of four prior cases suggest a link between phenformin and acute pancreatitis.
    • Three of the four previously reported patients also experienced lactic acidosis.
    • Phenformin's mechanism in causing pancreatitis is unknown, though it may affect pancreatic enzyme activity.

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    Implications:

    • Clinicians should consider phenformin as a potential cause of acute pancreatitis, especially in patients with lactic acidosis.
    • Further research is needed to elucidate the pathophysiology of phenformin-induced pancreatitis.
    • This association may inform drug safety monitoring and prescribing practices for phenformin.