Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mutations affecting craniofacial development in zebrafish

S C Neuhauss1, L Solnica-Krezel, A F Schier

  • 1Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA.

Development (Cambridge, England)
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What information can we gain from performing adaptive radiotherapy of head and neck cancer patients from the past 10 years?

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2021
Same author

Impact of COVID-19 on the performance of a radiation oncology department at a major comprehensive cancer centre in Poland during the first ten weeks of the epidemic.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology·2020
Same author

Low dose out-of-field radiotherapy, part 2: Calculating the mean photon energy values for the out-of-field photon energy spectrum from scattered radiation using Monte Carlo methods.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2017
Same author

Low dose out-of-field radiotherapy, part 1: Measurement of scattered doses.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2017
Same author

Low dose out-of-field radiotherapy, part 3: Qualitative and quantitative impact of scattered out-of-field radiation on MDA-MB-231 cell lines.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2017
Same author

Analysis of the retina in the zebrafish model.

Methods in cell biology·2016
Same journal

Dissecting planar and vertical organiser signals in early chick neural development.

Development (Cambridge, England)·2026
Same journal

Real-time transcriptomic profiling of hPSC-derived cartilage during development identifies a key role for the extracellular matrix in homeostasis and protection.

Development (Cambridge, England)·2026
Same journal

In preprints - housekeeping the housekeeping genes.

Development (Cambridge, England)·2026
Same journal

In preprints - light, cluster, friction: a cell dance on the gastrulation stage.

Development (Cambridge, England)·2026
Same journal

PBX-dependent and -independent Hox programs establish and maintain motor neuron terminal identity.

Development (Cambridge, England)·2026
Same journal

NUDT21 regulates 3'UTR dynamics in epididymal principal cells to preserve sperm integrity.

Development (Cambridge, England)·2026
See all related articles

Researchers identified 48 mutations affecting zebrafish craniofacial development. These mutations impact skeletal patterning, cartilage formation, and tissue interactions crucial for jaw development.

Area of Science:

  • Developmental Biology
  • Genetics
  • Zebrafish Embryogenesis

Background:

  • Craniofacial development is a complex process involving precise genetic control.
  • Understanding the genetic basis of craniofacial abnormalities is crucial for diagnosing and treating related disorders.

Purpose of the Study:

  • To identify genes regulating craniofacial development through a large-scale genetic screen in zebrafish.
  • To categorize mutations based on their effects on craniofacial skeletal patterning, cartilage development, and tissue interactions.

Main Methods:

  • Large-scale forward genetic screen in zebrafish to identify mutations affecting embryogenesis.
  • Analysis of craniofacial skeletal abnormalities in mutant zebrafish.
  • Gene expression analysis of marker genes in rhombencephalon, neural crest, and pharyngeal endoderm.

Related Experiment Videos

Main Results:

  • Identified 48 mutations in 34 genetic loci specifically affecting craniofacial development.
  • Mutations were categorized into three groups: affecting skeletal patterning, cartilage differentiation/morphogenesis, and skeletal element arrangement.
  • Expression studies revealed potential defects in neural crest and pharyngeal endoderm development.

Conclusions:

  • The identified genes play critical roles in distinct aspects of craniofacial development, including patterning, chondrogenesis, and tissue interactions.
  • This study provides a valuable resource for understanding the genetic control of jaw development and related congenital anomalies.