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Tendency toward atopy in Kawasaki disease
S Matsuoka1, K Tatara, R Nakagawa
1Department of Paediatrics, School of Medicine, Tokushima University, Japan.
Insights
Children with a history of Kawasaki disease (KD) show a higher incidence of allergic conditions like atopic dermatitis and allergic rhinitis. This suggests a potential genetic link between susceptibility to KD and atopy.
Area of Science:
- Pediatrics
- Immunology
- Allergy Research
Background:
- Kawasaki disease (KD) is a critical pediatric illness.
- The long-term sequelae of KD, particularly regarding allergic disease development, require further investigation.
Purpose of the Study:
- To investigate the potential trend of developing allergic diseases in children with a history of Kawasaki disease.
- To compare allergy incidence in KD patients versus age- and sex-matched controls.
Main Methods:
- A parental questionnaire was used to collect allergy-related data from 1,165 children with a history of KD.
- Data were compared with 5,825 sex- and age-matched control children.
- Incidence of household pets, family smoking, family history of allergy, atopic dermatitis, and allergic rhinitis were analyzed.
Main Results:
- Children with KD had a lower incidence of household pets and family smoking.
- A family history of allergy was more common in KD children (71%) than controls (56%).
- Incidence of atopic dermatitis and allergic rhinitis was significantly higher (1.7 times) in KD children, even without a family allergy history.
Conclusions:
- A genetic predisposition to atopy may be linked to Kawasaki disease susceptibility.
- Patients with KD demonstrate a tendency to develop atopic dermatitis and allergic rhinitis.
Unlabelled:
To evaluate the possible trend towards developing allergic disease in children who had suffered from Kawasaki disease (KD), we evaluated data related to allergy that were collected by parental questionnaire on 1,165 children who had suffered from KD. Comparisons were made with 5,825 sex- and age-matched control children. The incidence of household pets and of cigarette smoking in the family were significantly lower in the children with a history of KD than in those of control children. A family history of allergy was significantly more common in the children with a history of KD (71%) versus the controls (56%) (P < 0.001). The incidence of atopic dermatitis and of allergic rhinitis was significantly higher (by approximately 1.7 times) in the KD children versus the control group (P < 0.01), even in subgroups with no family history of allergy.
Conclusion:
We suggest that a genetic predisposition to atopy may be associated with a susceptibility to KD. Patients with KD tended to develop atopic dermatitis and allergic rhinitis.