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Borna disease virus RNA in peripheral blood mononuclear cells obtained from healthy dairy cattle
K Hagiwara1, T Nakaya, Y Nakamura
1Section of Serology, Hokkaido University, Sapporo, Japan.
Medical Microbiology and Immunology
|November 1, 1996
Abstract:
We examined natural infection of Borna disease virus (BDV) in 74 healthy dairy cattle in Japan. The seroprevalence determined using recombinant BDV p24 protein was 20.3%. The prevalence of BDV RNA in peripheral blood mononuclear cells (PBMCs) determined by polymerase chain reaction for p24 was 10.8%. Cell fraction of the PBMCs revealed the presence of BDV RNA in the T cell-enriched fraction. Thus, BDV infection is widespread even among healthy cattle.