Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

p53 expression in uveal malignant melanomas

V Jay1, Q Yi, W S Hunter

  • 1Department of Pathology, Hospital for Sick Children, Ontario, Canada.

Pathology
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Predictors of adverse outcomes in patients with chronic obstructive pulmonary disease and pulmonary embolism and the predictive value of the simplified pulmonary embolism severity index].

Zhonghua yi xue za zhi·2024
Same author

5 signature genes revealed by single-cell profiling identified unique immune subtypes affecting the prognosis of ovarian cancer.

European review for medical and pharmacological sciences·2024
Same author

[EHHADH is a key gene in fatty acid metabolism pathways in hepatocellular carcinoma: a transcriptomic analysis].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2023
Same author

[Clinical features and related factors of invasive pulmonary aspergillosis in patients with acute exacerbation of chronic obstructive pulmonary disease].

Zhonghua yi xue za zhi·2023
Same author

Fluid shear stress-induced down-regulation of miR-146a-5p inhibits osteoblast apoptosis via targeting SMAD4.

Physiological research·2022
Same author

Fluid Shear Stress Promotes Osteoblast Proliferation and Suppresses Mitochondrial-Mediated Osteoblast Apoptosis Through the miR-214-3p-ATF4 Signaling Axis.

Physiological research·2022
Same journal

Impact of the 2025 Endocrine Society clinical practice guideline on the diagnosis and management of primary aldosteronism for the clinical laboratory.

Pathology·2026
Same journal

Cribriform intraductal carcinoma of the prostate may have a greater prognostic impact even than Gleason grade 5 conventional prostatic adenocarcinoma.

Pathology·2026
Same journal

Bordetella pertussis: emerging epidemiology, diagnosis and management.

Pathology·2026
Same journal

Development and validation of a real-time polymerase chain reaction for the detection of Haycocknema perplexum.

Pathology·2026
Same journal

Recent advances in the understanding of TP53 in haematological malignancies.

Pathology·2026
Same journal

Concurrent renal amyloid light chain amyloidosis, light chain crystalline podocytopathy and light chain proximal tubulopathy: a case report.

Pathology·2026
See all related articles

p53 gene alterations are common in human cancers. This study found p53 positivity in mixed cell type uveal melanomas, suggesting p53 mutations may play a role in this specific cancer.

Area of Science:

  • Oncology
  • Genetics
  • Ophthalmology

Background:

  • The p53 gene, located on chromosome 17p, is frequently altered in human cancers.
  • Malignant melanoma is the most common intraocular neoplasm in adults.
  • Aberrant p53 expression is a common hallmark of many cancers.

Purpose of the Study:

  • To evaluate aberrant p53 expression in malignant melanoma, a common intraocular neoplasm.
  • To investigate the potential role of p53 gene alterations in the development of uveal melanomas.

Main Methods:

  • Immunohistochemistry was used to analyze 20 enucleation specimens, including ciliary body and choroidal melanomas, and choroidal nevi.
  • The D07 anti-p53 antibody and MIB-1 monoclonal antibody were utilized to assess p53 expression and cell proliferation.

Related Experiment Videos

  • Tumor types included spindle cell and mixed cell melanomas, as well as spindle cell nevi.

    • Main Results:

    • Of 18 melanomas studied, 13 cases exhibited nuclear p53 staining.
    • p53 positivity was observed in mixed cell type melanomas but not in spindle cell melanomas or choroidal nevi.
    • No correlation was found between the MIB-1 labelling index (cell proliferation) and p53 immunoreactivity in mixed cell type melanomas.

    Conclusions:

    • p53 alterations may occur in uveal melanomas.
    • p53 positivity was specifically found in malignant melanomas of the mixed cell type in this series.
    • These findings suggest a potential involvement of p53 gene mutations in the pathogenesis of mixed cell type uveal melanomas.