Diastolic heart failure. What primary care physicians need to know
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Updated: Nov 3, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
1Division of Cardiology, University of Chicago, Pritzker School of Medicine, IL, USA. kspencer@medicine.bsd.uchicago.edu
Insights
Congestive heart failure (CHF) with normal systolic function but abnormal diastolic function is common. Diagnosis relies on clinical suspicion and echocardiography, with treatment focusing on congestion and contributing factors.
Area of Science:
- Cardiology
- Heart Failure Research
Background:
- Congestive heart failure (CHF) with preserved ejection fraction (diastolic CHF) presents similarly to systolic dysfunction.
- Associated conditions include coronary artery disease, hypertension, and aging.
- Clinical presentation is often indistinguishable from systolic heart failure.
Purpose of the Study:
- To outline the diagnosis and management of diastolic CHF.
- To highlight the role of echocardiography in assessing diastolic function.
- To review current and potential therapeutic strategies.
Main Methods:
- Clinical suspicion of heart failure.
- Assessment of normal left ventricular systolic performance.
- Noninvasive evaluation of diastolic performance, primarily echocardiography.
- Identification of precipitating factors like ischemia and tachycardia.
Main Results:
- Diastolic CHF is characterized by normal left ventricular systolic function.
- Echocardiography is the most reliable noninvasive method for assessing diastolic function.
- Treatment focuses on managing pulmonary congestion with diuretics and nitrates.
Conclusions:
- Diastolic CHF requires a high index of clinical suspicion and specific diagnostic approaches.
- While no direct therapy improves diastolic function, certain medications like calcium channel blockers, beta blockers, and ACE inhibitors show promise.
- Management involves addressing precipitating factors and relieving congestion.
Abstract:
Congestive heart failure (CHF) with normal left ventricular systolic function and abnormal diastolic performance is a common clinical entity. Typically, signs and symptoms are indistinguishable from those of heart failure related to systolic dysfunction. Coronary artery disease, systemic hypertension, and aging are all associated with diastolic CHF. Diagnosis depends on a clinical suspicion of heart failure, followed by assessment of left ventricular systolic performance, which is normal in this condition. Ventricular diastolic performance can be assessed by noninvasive procedures, the most reliable and easily performed of which is echocardiography. General guidelines include searching for precipitants such as ischemia, tachycardia, and loss of atrial-ventricular synchrony. Treatment includes judicious use of nitrates and diuretics to relieve pulmonary congestion. There is no specific therapy to improve left ventricular diastolic function directly. However, calcium channel blockers and beta blockers are beneficial, and there is growing evidence that angiotensin-converting enzyme inhibitors may prove valuable.
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