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Adipocyte differentiation is regulated by a prostaglandin liganded to the nuclear peroxisome proliferator-activated
1Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
Nutrition Reviews
|September 1, 1996
Abstract:
Adipocyte differentiation and the homeostasis of fat cell number are regulated by a nuclear receptor protein, the peroxisome proliferator-activated receptor (PPAR gamma). The endogenous ligand is thought to be 15-deoxy-delta 12,14-prostaglandin J2-Thiazolidinedione, an antidiabetic drug, closely mimics the action of the prostaglandin, suggesting a regulatory role by the prostaglandin and PPAR gamma both in adipocyte differentiation and in glucose homeostasis.