Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

TRF1, a mammalian telomeric protein

S Smith1, T de Lange

  • 1Rockefeller University, New York, NY 10021, USA.

Trends in Genetics : TIG
|January 1, 1997
PubMed
Summary

Telomerase maintains mammalian chromosome ends by adding DNA repeats, preserving protective protein complexes. The isolation of TRF1 (telomeric-repeat binding factor) enables detailed study of this crucial telomeric complex.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidental finding of endolymphatic stromal myosis during luteinizing hormone releasing hormone agonist therapy for suspected benign uterine myomata. A case report.

The Journal of reproductive medicine·1992
Same author

Immunotherapy with a tumor-infiltrating lymphocyte clone, soluble antigen, and cyclophosphamide.

Archives of surgery (Chicago, Ill. : 1960)·1992
Same author

Respiratory epithelial cell invasion by group B streptococci.

Infection and immunity·1992
Same author

Psychiatrists and their patients--confidential information in the wake of spycatcher.

The Australian and New Zealand journal of psychiatry·1992
Same author

Continuous catheter drainage of Streptococcus pneumoniae pericardial effusion.

Journal of the Royal Society of Medicine·1992
Same author

Index of suspicion. Case 1. Diagnosis: Klinefelter syndrome.

Pediatrics in review·1992

Area of Science:

  • Genetics
  • Molecular Biology
  • Cell Biology

Background:

  • Telomeres are protective caps at the ends of mammalian chromosomes.
  • DNA replication naturally shortens telomeres.
  • Telomerase is an enzyme that adds DNA repeats to telomeres.

Purpose of the Study:

  • To explain the role of telomerase in maintaining telomeric DNA.
  • To highlight the importance of telomeric DNA in forming protective protein complexes.
  • To introduce the significance of the TRF1 protein in studying telomere structure and function.

Main Methods:

  • Review of telomere maintenance mechanisms.
  • Description of telomeric DNA functions.
  • Introduction of the TRF1 protein.

Main Results:

  • Telomerase replenishes terminal DNA sequence loss during replication.
  • Maintained telomeric DNA preserves binding sites for telomeric proteins.
  • The TRF1 protein is a key factor for examining the telomeric complex.

Conclusions:

  • Telomere maintenance by telomerase is essential for genomic stability.
  • Telomeric protein complexes provide crucial end protection.
  • TRF1 facilitates in-depth investigation of telomere structure and function.

Related Experiment Videos