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Related Experiment Videos

Progressive cerebral atrophy in multiple sclerosis. A serial MRI study

N A Losseff1, L Wang, H M Lai

  • 1NMR Research Unit, Institute of Neurology, London, UK.

Brain : a Journal of Neurology
|December 1, 1996
PubMed
Summary

We developed a new method to measure brain volume loss in multiple sclerosis (MS). This cerebral atrophy measurement is sensitive to disability worsening and offers insights beyond standard MRI scans.

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Spinal cord and cerebellar atrophy are linked to neurological impairment in multiple sclerosis (MS).
  • Cerebral white matter is also commonly affected pathologically in MS.
  • Quantifying cerebral atrophy is crucial for understanding MS progression.

Purpose of the Study:

  • To develop and validate a technique for quantifying cerebral white matter volume in MS patients.
  • To assess the relationship between cerebral atrophy and clinical disability progression.
  • To evaluate the utility of this technique in monitoring MS.

Main Methods:

  • Developed an image analysis algorithm to extract and quantify the volume of four contiguous 5 mm periventricular brain slices.
  • Assessed intra-observer scan-rescan reproducibility (0.56%).

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  • Applied the technique serially to 29 MS patients over 18 months.

    • Main Results:

    • Progressive cerebral atrophy was detected in 16 out of 29 patients over 18 months.
    • The rate of atrophy was significantly higher in patients with worsening Kurtzke Expanded Disability Status Scale (EDSS) scores.
    • No correlation was found between atrophy and baseline/changes in T2 lesion load or new gadolinium-enhancing lesions.

    Conclusions:

    • The developed technique reliably detects progressive cerebral atrophy in individual MS patients.
    • Cerebral atrophy progression correlates with worsening disability in MS.
    • This quantitative MRI measure provides valuable information beyond conventional MRI and can objectively assess therapeutic effects.