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Brain metastases in children with solid tumors

E Bouffet1, N Doumi, P Thiesse

  • 1Department of Pediatric Oncology, Centre Léon Bérard, Lyon, France.

Cancer
|January 15, 1997
PubMed
Summary
This summary is machine-generated.

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Brain metastases are an increasing concern in pediatric solid tumors due to improved survival. Despite intensive chemotherapy, the brain remains a challenge, with most patients experiencing poor outcomes.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Cancer Metastasis

Background:

  • Brain metastases are uncommon but increasingly recognized in pediatric solid tumors.
  • Improved survival rates heighten the risk period for pediatric patients.
  • This study reviews brain metastases in children treated between 1987-1995.

Purpose of the Study:

  • To analyze the incidence, characteristics, and outcomes of brain metastases in pediatric solid tumors.
  • To understand the impact of systemic chemotherapy on brain metastasis patterns.

Main Methods:

  • Retrospective review of 486 pediatric solid tumor patients.
  • Analysis of 12 cases with confirmed brain metastases.
  • Assessment of tumor type, clinical presentation, imaging, treatment, and outcomes.

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Main Results:

  • Ewing's sarcoma, neuroblastoma, and osteogenic sarcoma were most common causes.
  • 9 out of 12 patients had pre-existing metastatic disease at diagnosis.
  • Median time to brain metastasis detection was 15 months; outcomes were generally poor despite intensive therapy.

Conclusions:

  • Systemic chemotherapy has altered brain metastasis patterns in children.
  • The brain may be a sanctuary site for metastases, particularly in sarcoma and neuroblastoma.
  • Further research is needed to improve outcomes for pediatric brain metastases.