Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skull base chordomas: a management challenge

O al-Mefty1, L A Borba

  • 1Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, USA.

Journal of Neurosurgery
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Petroclival meningiomas: update of current treatment and consensus by the EANS skull base section.

Acta neurochirurgica·2021
Same author

Petroclival meningioma: case history and responses.

Skull base : official journal of North American Skull Base Society ... [et al.]·2006
Same author

Chordomas of the skull base: follow-up review and prognostic factors.

Neurosurgical focus·2006
Same author

Identification of isochromosome 1q as a recurring chromosome aberration in skull base chordomas: a new marker for aggressive tumors?

Neurosurgical focus·2006
Same author

Surgical seeding of chordomas.

Neurosurgical focus·2006
Same author

Growth dynamics of meningiomas in patients with multiple sclerosis treated with interferon: report of two cases.

Acta neurochirurgica·2002
Same journal

A novel surgical T staging system for recurrent nasopharyngeal carcinoma: advancing prognostic accuracy and clinical applicability.

Journal of neurosurgery·2026
Same journal

De novo aneurysm formation and untreated aneurysm growth after microsurgical clipping: a 20-year prospective cohort study.

Journal of neurosurgery·2026
Same journal

Immune and clinicopathological features of molecularly defined prolactinoma subtypes.

Journal of neurosurgery·2026
Same journal

A nomogram predicting postoperative recurrence risk in SF1/TPIT nonfunctioning pituitary neuroendocrine tumors: integration of tumor heterogeneity quantification on T2-weighted imaging.

Journal of neurosurgery·2026
Same journal

Resection plus stereotactic radiosurgery versus stereotactic radiosurgery alone and control of brain metastasis-induced seizures.

Journal of neurosurgery·2026
Same journal

Predictors of ventricular shunt survival in neoplastic hydrocephalus: a retrospective cohort study of 239 patients.

Journal of neurosurgery·2026
See all related articles

Radical surgery combined with proton-photon beam therapy offers effective treatment for challenging skull base chordomas, improving tumor control and survival rates. This approach demonstrates early promise for managing these aggressive tumors.

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Skull base chordomas are difficult to treat due to their location, invasiveness, and recurrence.
  • Radical surgical removal and high-dose radiation, especially proton beam therapy, are known to improve tumor control and survival.

Purpose of the Study:

  • To evaluate the efficacy of radical surgery followed by proton-photon beam therapy for skull base chordomas.
  • To assess treatment outcomes, including recurrence rates, survival, and complications.

Main Methods:

  • Retrospective analysis of 25 patients with skull base chordomas treated over 5 years.
  • Surgical procedures included radical, subtotal, and partial resections, with extensive bone drilling.
  • Adjuvant therapy involved postoperative proton-photon beam therapy, conventional radiation, or no adjunct therapy.

Related Experiment Videos

Main Results:

  • Radical or subtotal resection was achieved in 21 out of 23 patients.
  • 16 out of 21 patients followed for over 3 months showed no evidence of recurrence.
  • Four patients died, two from tumor recurrence; complications included neurological deficits and radiation necrosis.

Conclusions:

  • Radical surgical removal combined with postoperative proton-photon beam therapy shows early promise for effective treatment of skull base chordomas.
  • Skull base approaches based on tumor classification are associated with low mortality and morbidity rates.