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Squamometry in rating the efficacy of topical corticosteroids in atopic dermatitis
C Letawe1, C Piérard-Franchimont, G E Piérard
1Department of Dermatopathology, University of Liège, Belgium.
European Journal of Clinical Pharmacology
|January 1, 1996
Abstract
Objective:
Squamometry is a non-invasive test allowing a reproducible rating of cutaneous xerosis including atopic dermatitis lesions. The method was used to compare the efficacy of proprietary topical corticosteroids in alleviating signs of atopic xerosis.
Results:
The steroid compounds and their vehicles improve the texture of the stratum corneum at different rates after treatment for 1 week. Some differences in efficacy may be explained by the nature of the vehicle, which enhances the basic pharmacological activity of the corticosteroid itself.