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Time-dependent variability of chloroquine secretion into human saliva
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
Pharmacy World & Science : PWS
|December 1, 1996
Summary
Chloroquine is secreted into human saliva, with concentrations correlating well with plasma levels after oral administration. Saliva monitoring for chloroquine may require caution due to high, variable saliva-to-plasma ratios.
Area of Science:
- Pharmacology
- Analytical Chemistry
- Clinical Medicine
Background:
- Chloroquine is known to be secreted into human saliva.
- Understanding the pharmacokinetics of chloroquine in saliva is crucial for potential therapeutic monitoring.
Purpose of the Study:
- To investigate the correlation between chloroquine concentrations in plasma and saliva.
- To evaluate the utility of saliva for therapeutic drug monitoring of chloroquine.
Main Methods:
- Administration of chloroquine (600 mg oral, 150 mg intramuscular) to human volunteers.
- Simultaneous collection of blood and saliva samples.
- Analysis of chloroquine concentrations using High-Performance Liquid Chromatography (HPLC).
Main Results:
- Peak plasma and saliva chloroquine concentrations occurred simultaneously after oral administration.
- A strong correlation was observed between Area Under the Curve (AUC) values from saliva and plasma.
- High mean saliva-to-plasma concentration ratios (>11) were recorded, showing time-dependent variability.
Conclusions:
- Chloroquine transfer into saliva may involve active transport mechanisms.
- Saliva can be a useful matrix for chloroquine analysis, correlating well with plasma levels.
- Caution is advised for using saliva for therapeutic monitoring of chloroquine due to concentration variability.